Aedes aegypti anti-salivary proteins IgG levels in a cohort of DENV-like symptoms subjects from a dengue-endemic region in Colombia

Dengue fever, caused by the dengue virus (DENV), is currently a threat to about half of world's population. DENV mainly transmitted vertebrate host through bite female Aedes mosquito while taking blood meal. During this process, salivary proteins are introduced into skin and facilitate acquisition. These modulate both local (skin) systemic immune responses. Several have been identified as immunogenic inducing production antibodies with some those also displaying immunomodulatory properties enhancing arboviral infections. IgG antibody responses against gland extracts diverse number mosquitoes, well Ae. aegypti peptide, Nterm-34 kDa, suggested biomarkers human exposure bites AgBR1 NeSt1 investigated for their potential protective effect Zika (ZIKV) West Nile Thus, we were interested in evaluating whether AgBR1, NeSt1, kDa SGE associated infections clinical characteristics. For this, tested samples from volunteers living fever endemic area Colombia 2019 presence peptides using an ELISA test. Results pilot study suggest involvement disease progression.